The doctors have said that the new treatment can improve response rates (increase the rate of tumour shrinkage) and delay cancer progression.
"Trebananib is a first-in-class peptide-Fc fusion protein (or peptibody) that targets angiogenesis (the growth of new blood vessels into cancerous tumours) by inhibiting the binding of both angiopoietin 1 and 2 to the Tie2 receptor," researchers said.
This is very different mechanism of action than other agents that also effect angiogenesis by inhibiting vascular endothelial growth factor (VEGF) such as bevacizumab, they said.
Researchers said trebananib does not increase the risks of hypertension and bowel perforation like bevaciuzmab but still has a similar impact on tumour shrinkage and delaying cancer progression.
A randomized clinical trial added trebananib or placebo to standard chemotherapy (weekly paclitaxel) among 919 women with recurrent ovarian cancer patient from 179 sites in 32 countries.
The trial, dubbed TRINOVA-1, was run by Professor Bradley J Monk who directs the Division of Gynaecologic Oncology at the University of Arizona Cancer Centre at St Joseph's in Phoenix.
"This is an exciting new targeted medication in treating recurrent ovarian cancer. Recurrent ovarian cancer is almost always fatal and new treatments are desperately needed," said Monk.
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